Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2

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 Un estudio de investigadores de la Universitat de Barcelona (UB), el Institut de Recerca Biomèdica (IRB) y el Centre de Recerca Biomèdica en Xarxa de Diabetis i Malalties Metabòliques Associades (CIBERDEM) han identificado un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2. El trabajo, publicado en la revista 'Redox Biology', ha descrito en muestras de pacientes y en un modelo animal de diabetes de tipo 2 una "disminución de las proteínas mitocondriales que se encargan de sintetizar subunidades de los complejos de la cadena respiratoria celular", ha informado la UB en un comunicado de este jueves. Los investigadores han analizado muestras musculares de pacientes obesos con diabetes de tipo 2 (que suele desarrollarse en torno a los 55 años), pacientes obesos con diabetes de inicio precoz (que aparece en torno a los 25 años) y en un modelo animal de diabetes. Las mitocondrias son los orgánulos encargados de producir la energía celular, y "existen evidencias que relacionan disfunciones en su funcionamiento con la resistencia a la insulina característica de la diabetes de tipo 2", por lo que el objetivo era determinar si existían alteraciones que pudieran estar asociadas y si el óxido nítrico está involucrado en estas alteraciones. Los resultados han mostrado que la disfunción mitocondrial se asocia a un incremento del óxido nítrico intracelular que, según los investigadores, "podría ser un método de diagnóstico de la enfermedad" y sobre los efectos de las enzimas que producen óxido nítrico. Asimismo, permitirán estudiar el efecto de la abundancia de las ARNmt sintetasas, y su relación con la síntesis de proteínas mitocondriales.  
 
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 ∞ (Recursion)
 - #formatter (String, 28 characters ) taxonomy_term_reference_link
 - 0 (Array, 4 elements)
 
 #type (String, 4 characters ) link | (Callback) link();
 
 #title (String, 7 characters ) estudio
 
 #href (String, 19 characters ) taxonomy/term/21395
 
 #options (Array, 3 elements)
 
 entity_type (String, 13 characters ) taxonomy_term
 
 entity (Object) stdClass
 
 ∞ (Recursion)
 
 attributes (Array, 3 elements)
 
 typeof (Array, 1 element)
 
 0 (String, 12 characters ) skos:Concept
 
 property (Array, 2 elements)
 
 0 (String, 10 characters ) rdfs:label
 
 1 (String, 14 characters ) skos:prefLabel
 
 datatype (String, 0 characters )
 - 1 (Array, 4 elements)
 
 #type (String, 4 characters ) link | (Callback) link();
 
 #title (String, 18 characters ) diabetes de tipo 2
 
 #href (String, 19 characters ) taxonomy/term/49615
 
 #options (Array, 3 elements)
 
 entity_type (String, 13 characters ) taxonomy_term
 
 entity (Object) stdClass
 
 ∞ (Recursion)
 
 attributes (Array, 3 elements)
 
 typeof (Array, 1 element)
 
 0 (String, 12 characters ) skos:Concept
 
 property (Array, 2 elements)
 
 0 (String, 10 characters ) rdfs:label
 
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 datatype (String, 0 characters )
- field_noticia_fecha (Array, 16 elements)
 - #theme (String, 5 characters ) field
 - #weight (String, 1 characters ) 8
 - #title (String, 5 characters ) Fecha
 - #access (Boolean) TRUE
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 - #object (Object) stdClass
 
 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 4 elements)
 
 value (String, 19 characters ) 2023-03-23 12:47:00
 
 timezone (String, 14 characters ) America/La_Paz
 
 timezone_db (String, 3 characters ) UTC
 
 date_type (String, 8 characters ) datetime
 - #formatter (String, 12 characters ) date_default
 - 0 (Array, 1 element)
 
 #markup (String, 150 characters ) Jueves, 23 Marzo, 2023 - 08:47
- field_autor (Array, 16 elements)
 - #theme (String, 5 characters ) field
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 - #title (String, 5 characters ) Autor
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 - #object (Object) stdClass
 
 ∞ (Recursion)
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 0 (Array, 3 elements)
 
 target_id (String, 6 characters ) 110251
 
 entity (Object) stdClass
 
 ∞ (Recursion)
 
 access (Boolean) TRUE
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 #theme (String, 21 characters ) entityreference_label
 
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 entity (Object) stdClass
 
 ∞ (Recursion)
 
 access (Boolean) TRUE
 
 #uri (Array, 2 elements)
 
 path (String, 11 characters ) node/110251
 
 options (Array, 2 elements)
 
 entity_type (String, 4 characters ) node
 
 entity (Object) stdClass
 
 ∞ (Recursion)
 
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 link (Integer) 1
 
 bypass_access (Boolean) FALSE
 
 colorbox_node_link (Boolean) FALSE
 
 colorbox_node_classes (String, 0 characters )
 
 colorbox_node_width (String, 3 characters ) 600
 
 colorbox_node_height (String, 3 characters ) 600
 
 field (Array, 4 elements)
 
 target_type (String, 4 characters ) node
 
 handler (String, 4 characters ) base
 
 handler_settings (Array, 3 elements)
 
 target_bundles (Array, 1 element)
 
 autor (String, 5 characters ) autor
 
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 type (String, 4 characters ) none
 
 behaviors (Array, 1 element)
 
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 behaviors (Array, 0 elements)
- field_noticia_fuente (Array, 16 elements)
 - #theme (String, 5 characters ) field
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 ∞ (Recursion)
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 0 (Array, 1 element)
 
 value (String, 5 characters ) cable
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 - #theme (String, 8 characters ) bxslider
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 - #title (String, 16 characters ) Fotos / Galería
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 - #field_name (String, 19 characters ) field_noticia_fotos
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 - #bundle (String, 7 characters ) noticia
 - #object (Object) stdClass
 
 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 2 elements)
 
 item (Array, 18 elements)
 
 fid (String, 6 characters ) 586178
 
 uid (String, 5 characters ) 10198
 
 filename (String, 12 characters ) diabetes.jpg
 
 uri (String, 44 characters ) public://media_imagen/2023/3/23/diabetes.jpg
 
 filemime (String, 10 characters ) image/jpeg
 
 filesize (String, 5 characters ) 30252
 
 status (String, 1 characters ) 1
 
 timestamp (String, 10 characters ) 1699967961
 
 type (String, 5 characters ) image
 
 field_file_image_description (Array, 1 element)
 
 und (Array, 1 element)
 
 0 (Array, 3 elements)
 
 value (String, 81 characters ) Un sanitario mide el nivel de azúcar en sangre ...
 
 Un sanitario mide el nivel de azúcar en sangre a un paciente. (Foto referencial)
 
 format (NULL)
 
 safe_value (String, 81 characters ) Un sanitario mide el nivel de azúcar en sangre ...
 
 Un sanitario mide el nivel de azúcar en sangre a un paciente. (Foto referencial)
 
 field_file_image_credits (Array, 1 element)
 
 und (Array, 1 element)
 
 0 (Array, 3 elements)
 
 value (String, 8 characters ) Internet
 
 format (NULL)
 
 safe_value (String, 8 characters ) Internet
 
 rdf_mapping (Array, 0 elements)
 
 path (Array, 1 element)
 
 pathauto (String, 1 characters ) 1
 
 metadata (Array, 2 elements)
 
 height (Integer) 430
 
 width (Integer) 765
 
 height (String, 3 characters ) 430
 
 width (String, 3 characters ) 765
 
 alt (NULL)
 
 title (NULL)
 
 slide (String, 196 characters ) <img typeof="foaf:Image" class="image-style-not...
 
 <img typeof="foaf:Image" class="image-style-noticia-detalle" src="https://www.lostiempos.com/sites/default/files/styles/noticia_detalle/public/media_imagen/2023/3/23/diabetes.jpg?itok=pBUDXCQ6" />
 - #formatter (String, 8 characters ) bxslider
 - #settings (Array, 2 elements)
 
 slider_id (String, 19 characters ) field_noticia_fotos
 
 slider_settings (Array, 47 elements)
 
 mode (String, 10 characters ) horizontal
 
 speed (Integer) 500
 
 slideMargin (Integer) 0
 
 startSlide (Integer) 0
 
 randomStart (Integer) 0
 
 infiniteLoop (Integer) 0
 
 hideControlOnEnd (Integer) 1
 
 easing (String, 0 characters )
 
 captions (Integer) 1
 
 ticker (Integer) 0
 
 tickerHover (Integer) 0
 
 adaptiveHeight (Integer) 0
 
 adaptiveHeightSpeed (Integer) 500
 
 video (Integer) 0
 
 responsive (Integer) 1
 
 useCSS (Integer) 1
 
 preloadImages (Integer) 0
 
 swipeThreshold (Integer) 50
 
 oneToOneTouch (Integer) 1
 
 preventDefaultSwipeX (Integer) 1
 
 preventDefaultSwipeY (Integer) 0
 
 pager (Integer) 1
 
 pagerType (String, 5 characters ) short
 
 pagerShortSeparator (String, 3 characters ) /
 
 pagerSelector (String, 0 characters )
 
 pagerCustom_type (String, 4 characters ) none
 
 pagerCustom_image_style (String, 9 characters ) thumbnail
 
 controls (Integer) 1
 
 nextText (String, 4 characters ) Next | (Callback) Next();
 
 prevText (String, 4 characters ) Prev | (Callback) Prev();
 
 nextSelector (String, 0 characters )
 
 prevSelector (String, 0 characters )
 
 autoControls (Integer) 0
 
 startText (String, 5 characters ) Start
 
 stopText (String, 4 characters ) Stop
 
 autoControlsCombine (Integer) 0
 
 autoControlsSelector (String, 0 characters )
 
 auto (Integer) 0
 
 pause (Integer) 4000
 
 autoStart (Integer) 1
 
 autoDirection (String, 4 characters ) next | (Callback) next();
 
 autoHover (Integer) 0
 
 autoDelay (Integer) 0
 
 minSlides (Integer) 1
 
 maxSlides (Integer) 1
 
 moveSlides (Integer) 0
 
 slideWidth (Integer) 0
- field_noticia_count_face (Array, 16 elements)
 - #theme (String, 5 characters ) field
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 - #title (String, 17 characters ) Contador Facebook
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 - #field_name (String, 24 characters ) field_noticia_count_face
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 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 1 element)
 
 value (String, 1 characters ) 0
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 - #theme (String, 5 characters ) field
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 - #title (String, 16 characters ) Contador Twitter
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 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 1 element)
 
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- field_noticia_count_social_total (Array, 16 elements)
 - #theme (String, 5 characters ) field
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 - #title (String, 21 characters ) Contador Social Total
 - #access (Boolean) TRUE
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 - #field_name (String, 32 characters ) field_noticia_count_social_total
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 - #object (Object) stdClass
 
 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 1 element)
 
 value (String, 1 characters ) 0
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- field_noticia_fecha_simple (Array, 16 elements)
 - #theme (String, 5 characters ) field
 - #weight (String, 2 characters ) 21
 - #title (String, 12 characters ) Fecha Simple
 - #access (Boolean) TRUE
 - #label_display (String, 6 characters ) hidden
 - #view_mode (String, 4 characters ) full
 - #language (String, 3 characters ) und
 - #field_name (String, 26 characters ) field_noticia_fecha_simple
 - #field_type (String, 8 characters ) datetime
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 - #object (Object) stdClass
 
 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 4 elements)
 
 value (String, 19 characters ) 2023-03-23 00:00:00
 
 timezone (String, 14 characters ) America/La_Paz
 
 timezone_db (String, 14 characters ) America/La_Paz
 
 date_type (String, 8 characters ) datetime
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 #markup (String, 142 characters ) Jueves, 23 Marzo, 2023
- field_noticia_mult_principal (Array, 16 elements)
 - #theme (String, 5 characters ) field
 - #weight (String, 1 characters ) 1
 - #title (String, 20 characters ) Multimedia principal
 - #access (Boolean) TRUE
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 - #field_name (String, 28 characters ) field_noticia_mult_principal
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 - #object (Object) stdClass
 
 ∞ (Recursion)
 - #items (Array, 1 element)
 
 0 (Array, 1 element)
 
 value (String, 1 characters ) 1
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 #markup (String, 15 characters ) Foto / Galería
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- #entity_type (String, 4 characters ) node
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 0 (String, 23 characters ) drupal_pre_render_links | (Callback) drupal_pre_render_links();
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 #theme (String, 17 characters ) links__node__node
 
 #links (Array, 0 elements)
 
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 class (Array, 2 elements)
 
 0 (String, 5 characters ) links
 
 1 (String, 6 characters ) inline
 - comment (Array, 3 elements)
 
 #theme (String, 20 characters ) links__node__comment
 
 #links (Array, 0 elements)
 
 #attributes (Array, 1 element)
 
 class (Array, 2 elements)
 
 0 (String, 5 characters ) links
 
 1 (String, 6 characters ) inline
- comments (Array, 0 elements)
- rate_valoracion_noticia (Array, 4 elements)
 - #weight (Integer) 50
 - #markup (String, 1383 characters ) <div class="rate-widget-1 rate-widget clear-blo...
 
 <div class="rate-widget-1 rate-widget clear-block rate-average rate-widget-emotion rate-73dd3aedc3df289b877d289e30a53fd0 rate-node-595173-1-1" id="rate-node-595173-1-1"><div class="item-list"><ul><li class="item-0 even first"><a class="rate-button rate-emotion-btn" id="rate-button-1" rel="nofollow" href="/node/595173/devel/render?rate=rcDFrlRzVBSQIfb_JKuEugBE87Xtj-Kr5G4dBCaF-_A" title="Indignado">Indignado</a>21</li><li class="item-1 odd"><a class="rate-button rate-emotion-btn" id="rate-button-2" rel="nofollow" href="/node/595173/devel/render?rate=Mi5Wzrlm8UpREB7Ell77F8DLmCFEuoKenv2VUvUTQcw" title="Triste">Triste</a>24</li><li class="item-2 even"><a class="rate-button rate-emotion-btn" id="rate-button-3" rel="nofollow" href="/node/595173/devel/render?rate=xaaRpQzIBfIpvx4ZbS2MtdeL_E21c881vfrEEwF6NGk" title="Indiferente">Indiferente</a>22</li><li class="item-3 odd"><a class="rate-button rate-emotion-btn" id="rate-button-4" rel="nofollow" href="/node/595173/devel/render?rate=DnB8lgVj0QbRXqJ1abgVIXQBwDWjDf8mqMoTD-ersXQ" title="Sorprendido">Sorprendido</a>27</li><li class="item-4 even last"><a class="rate-button rate-emotion-btn" id="rate-button-5" rel="nofollow" href="/node/595173/devel/render?rate=pEtMJRRd-jc6Pg9clQ-B3uK5Z4hGmqhxrEF8uehGAy4" title="¡Me gusta!">¡Me gusta!</a>59</li></ul></div></div>
 - #title (String, 19 characters ) Valora esta noticia
 - #type (String, 4 characters ) item
- sharethis (Array, 5 elements)
 - #tag (String, 3 characters ) div
 - #type (String, 8 characters ) html_tag
 - #attributes (Array, 1 element)
 
 class (Array, 1 element)
 
 0 (String, 17 characters ) sharethis-buttons
 - #value (String, 2671 characters ) <div class="sharethis-wrapper"><span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_facebook&amp;quot_button" displayText="facebook&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_twitter&amp;quot_button" displayText="twitter&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_linkedin&amp;quot_button" displayText="linkedin&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_email&amp;quot_button" displayText="email&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_sharethis&amp;quot_button" displayText="sharethis&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_pinterest&amp;quot_button" displayText="pinterest&amp;amp;quot"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_plusone_button" displayText="plusone"> <span st_url="https://www.lostiempos.com/tendencias/salud/20230323/estudio-identifica-mecanismo-molecular-implicado-desarrollo-diabetes-tipo" st_title="Un estudio identifica un mecanismo molecular implicado en el desarrollo de la diabetes de tipo 2" class="st_fblike_button" displayText="fblike"> </div>
 - #weight (Integer) 10
- #view_mode (String, 4 characters ) full
- #theme (String, 4 characters ) node
- #node (Object) stdClass
 - ∞ (Recursion)
- #language (String, 2 characters ) es
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Krumo version 0.2.1a